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miR-150-mediated Foxo1 regulation programs CD8+ T-cell differentiation

miR-150-mediated Foxo1 regulation programs CD8+ T-cell differentiation : 작성자, 작성일, 조회수, 저자,링크,대표이미지 첨부파일 정보 제공
작성자 유미경
작성일 2017-12-19 조회수 620
저자 Young Ho Ban, Se-Chan Oh, Sang-Hwan Seo, Seok-Min Kim, In-Pyo Choi, Philip D. Greenberg, Jun Chang, Tae-Don Kim, Sang-Jun Ha
링크 http://www.sciencedirect.com/science/article/pii/S2211124717311907?via%3Dihub
45-Cell_Rep-김태돈170912.pdf_page_02.jpg
첨부파일

MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8+ T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8+ T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8+ T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8+ T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8+ T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics.