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MicroRNA-150 controls differentiation of intraepithelial lymphocyte via TGFb receptor II regulation

MicroRNA-150 controls differentiation of intraepithelial lymphocyte via TGFb receptor II regulation : 작성자, 작성일, 조회수, 저자,링크,대표이미지 첨부파일 정보 제공
작성자 유미경
작성일 2017-12-19 조회수 642
저자 Sang-HwanSeo, Min Seong Jang, Doo-Jin Kim, Seok-Min Kim, Se-Chan Oh, Cho-Rok Jung, Yunji Park, Sang-Jun Ha, Haiyoung Jung, Young-Jun Park, Suk Ran Yoon,Inpyo Choi, Tae-Don Kim
링크 http://www.sciencedirect.com/science/article/pii/S0091674917312757?via%3Dihub
46-JACI-김태돈_교신171120.pdf_page_01.jpg
첨부파일
miR-150 deficiency reduced the IEL population in the small intestine and increased susceptibility to methotrexate-induced mucositis. Evaluation of expression of IEL differentiation–associated molecules showed that miR-150–deficient IELs exhibited decreased expression of TGF-β receptor (TGF-βR) II, CD103, CD8αα, and Runt-related transcription factor 3 in all the IEL subpopulations. The reduced expression of TGF-βRII in miR-150–deficient IELs was caused by increased expression of c-Myb/miR-20a. Restoration of miR-150 or inhibition of miR-20a recovered the TGF-βRII expression.